Ancestry painting with local ancestry inference

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The 23Andme, Inc. patent solves the following problem:

Ancestry deconvolution aims to recognize the ancestral origin of chromosomal people. Ancestry deconvolution admixed individuals (ie, those whose ancestors as grandparents from different regions) is straightforward when the global population considered sufficient (for example, a grandfather from Europe and one from Asia). To date, however, current methods are often not effective in distinguishing between closely related populations (eg, in Europe). Furthermore, because of their computational complexity, the current procedures for background deconvolution not good for application in setting large-scale, which references ornaments used include thousands of people.

Our analysis of this patent is as follows:

23Andme, Inc.’s patent US 9367800 B1 deals with Ancestry painting with local ancestry inference.
Presenting ancestral origin of information, comprising: receiving a request to display genealogical data to an individual; obtaining background information on composition of each, the ethnic composition information including information about a number of genotype data of individuals, considered to be equivalent to a specific origin; and presenting the ancestors composition information shown.

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Trio-based phasing using a dynamic Bayesian network

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The 23Andme, Inc. patent solves the following problem:

Ancestry deconvolution aims to recognize the ancestral origin of chromosomal people. Ancestry deconvolution admixed individuals (ie, those whose ancestors as grandparents from different regions) is straightforward when the global population considered sufficient (for example, a grandfather from Europe and one from Asia). To date, however, current methods are often not effective in distinguishing between closely related populations (eg, in Europe). Furthermore, because of their computational complexity, the current procedures for background deconvolution not good for application in setting large-scale, which references ornaments used include thousands of people.

Our analysis of this patent is as follows:

23Andme, Inc.’s patent US 9213944 B1 deals with Trio-based phasing using a dynamic Bayesian network.
Do three-based elimination include: earn a set of preliminary data on haplotype a man; build a dynamic Bayesian network based at least in part on the preliminary set of haplotype data on individuals and on the haplotype data with at least one parent of the individual; and determine, based on dynamic Bayesian network, a set of refined haplotype data individually.

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Scalable pipeline for local ancestry inference

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The 23Andme, Inc. patent solves the following problem:

Ancestry deconvolution aims to recognize the ancestral origin of chromosomal people. Ancestry deconvolution admixed individuals (ie, those whose ancestors as grandparents from different regions) is straightforward when the global population considered sufficient (for example, a grandfather from Europe and one from Asia). To date, however, current methods are often not effective in distinguishing between closely related populations (eg, in Europe). Furthermore, because of their computational complexity, the current procedures for background deconvolution not good for application in setting large-scale, which references ornaments used include thousands of people.

Our analysis of this patent is as follows:

23Andme, Inc.’s patent US 9213947 B1 deals with Scalable pipeline for local ancestry inference.
Ancestry deconvolution includes gain unphased genotype data in an individual; destroy, to use one or more processors, unphased genotype data creation of haplotype data; Using a machine learning to classify the portion of lost data haplotype as equivalent in certain ancestries individuals and create initial classification results; and correction of errors in the classification results in the creation of modified classification results.

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Automated system for the comparison of individual genome, transcriptome, proteome, epigenome, and metabolome data with data from bonemarrow donor registers and blood banks, umbilical cord blood banks and tissue banks

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The Cytolon Ag patent solves the following problem:

Our analysis of this patent is as follows:

Cytolon Ag’s patent US 8788214 B2 deals with Automated system for the comparison of individual genome, transcriptome, proteome, epigenome, and metabolome data with data from bonemarrow donor registers and blood banks, umbilical cord blood banks and tissue banks.
The invention relates to a system for the automatic, rapid and dynamic allocation of biological cells for transplantation, therapy, or research purposes between the central bank or collection (storage) and hospitals, transplant center or research facilities, and to monitor and support the process of transmission to request delivery of a cell preparation suitable for allogeneic transplantation, through the use of budget preparation in tracking the results to patients and to provide these data for statistical and other purposes, as well as providing molecular diagnostic results in individuals with the aim to determine optionseven advanceof transplantations among the inventory register or banks. Using the said system, it is possible that the first road timeeven and online and with automatic retriesto offer complete solutions in the form of transplantations specific and individual cases.

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Gamete donor selection based on genetic calculations

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The 23Andme, Inc. patent solves the following problem:

Gamete storage facilities like a seed / egg bank making more people have greater control and more choice in reproduction. At present, some facilities in collecting the sperm or egg donation as well as certain profile information about the donors. Such information generally includes the donor race, height, weight, age, blood type, health condition, eye color, educational background, family history, and with a potential recipient can review the profile and make a choice. Although the personal profiles of donors can serve a useful purpose for the potential recipient to make a better choice, the information is usually offered only limited understanding for recipients with specific concerns about certain genetic traits, such as hereditary diseases, to make a truly informed choice. For example, a recipient of a family history of breast cancer may worry about receiving a donation from a man who was also a high risk group; however, if the family history information is incomplete or unavailable, have not been able to make an informed choice.

Our analysis of this patent is as follows:

23Andme, Inc.’s patent US 8543339 B2 deals with Gamete donor selection based on genetic calculations.
Gamete donor selection includes receiving a call including a phenotype of interest, accepting a genotype one receiving a plurality of genotypes in a respective plurality of donors, determine statistical information about the phenotype of interest based at least in part to different pairings genotype recipient and a genotype of a donor plurality of donors, and the recognition of a donor among the plurality of donors, based at least in part on statistical information determined.

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