Processing data from genotyping chips

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The 23Andme, Inc. patent solves the following problem:

The instructions for making cells in the human body is encoded in deoxyribonucleic acid (DNA). DNA is a long, ladder-shaped molecule, each equivalent to climb up on a pair of interlocking units, called bases, appointed by the four letters of DNA AlphaBeta, T, G and C. a always pairs or chains with T, and G always pairs or chains with C. the order of these four letters in one DNA called human genome.

Our analysis of this patent is as follows:

23Andme, Inc.’s patent US 9218451 B2 deals with Processing data from genotyping chips.
Processing genetic data includes receiving two or more sets of genetic data for an individual from one or more genetic source of data, where the genetic data set contains the data of deoxyribonucleic acid individuals (DNA); combining the genetic data sets from one or more genetic data sources to obtain a set of merged genetic data for each, including: identifying genetic data sets of data contradictory, acknowledged that data corresponding to a genetic marker associated with a difference that takes place in a region of the human genome; analyzing the identified data to resolve a dispute dedicated to recognizing conflicting data and automatically determine a proper value corresponding to the genetic mark, the analysis and the determination based at least part of the contextual information; and gather the appropriate value of the set of merged genetic data.

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Scalable pipeline for local ancestry inference

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The 23Andme, Inc. patent solves the following problem:

Ancestry deconvolution aims to recognize the ancestral origin of chromosomal people. Ancestry deconvolution admixed individuals (ie, those whose ancestors as grandparents from different regions) is straightforward when the global population considered sufficient (for example, a grandfather from Europe and one from Asia). To date, however, current methods are often not effective in distinguishing between closely related populations (eg, in Europe). Furthermore, because of their computational complexity, the current procedures for background deconvolution not good for application in setting large-scale, which references ornaments used include thousands of people.

Our analysis of this patent is as follows:

23Andme, Inc.’s patent US 9213947 B1 deals with Scalable pipeline for local ancestry inference.
Ancestry deconvolution includes gain unphased genotype data in an individual; destroy, to use one or more processors, unphased genotype data creation of haplotype data; Using a machine learning to classify the portion of lost data haplotype as equivalent in certain ancestries individuals and create initial classification results; and correction of errors in the classification results in the creation of modified classification results.

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Trio-based phasing using a dynamic Bayesian network

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The 23Andme, Inc. patent solves the following problem:

Ancestry deconvolution aims to recognize the ancestral origin of chromosomal people. Ancestry deconvolution admixed individuals (ie, those whose ancestors as grandparents from different regions) is straightforward when the global population considered sufficient (for example, a grandfather from Europe and one from Asia). To date, however, current methods are often not effective in distinguishing between closely related populations (eg, in Europe). Furthermore, because of their computational complexity, the current procedures for background deconvolution not good for application in setting large-scale, which references ornaments used include thousands of people.

Our analysis of this patent is as follows:

23Andme, Inc.’s patent US 9213944 B1 deals with Trio-based phasing using a dynamic Bayesian network.
Do three-based elimination include: earn a set of preliminary data on haplotype a man; build a dynamic Bayesian network based at least in part on the preliminary set of haplotype data on individuals and on the haplotype data with at least one parent of the individual; and determine, based on dynamic Bayesian network, a set of refined haplotype data individually.

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Specimen sample collection system

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The Oasis Diagnostics, Corporation patent solves the following problem:

Over the last few years there was a large increase in area of ​​salivary diagnostics, prompted in part by efforts from the National Institutes of Health (NIH) and the National Institute of Dental and Craniofacial Research (NIDCR) division to improve development of non-invasive technology for the diagnosis of disease and to measure specific analytes or molecules in saliva or oral fluid sample. These agencies make funds available for the development of novel, innovative tools including microarrays, lab-on-a-chip, lateral flow, ELISA and other technologies to use saliva and other non- invasive sampling method. Some reasons for the increased interest in salivary diagnostics involves the development of important new technologies for the collection and testing of oral fluids and improvements in the manufacturability of such devices.

Our analysis of this patent is as follows:

Oasis Diagnostics, Corporation’s patent US 9198641 B2 deals with Specimen sample collection system.
A specimen sample collection system includes a handle having opposed first and second ends, and a sufficient sign with the shaft, wherein the second end management and sufficiency indicator of a hole adapted to receive a sample collection pad; a sample collection pad with opposing ends, the sample collection pad partially within and extending from the direction of the second end, and in contact with enough evidence, the sample collection pad with a cylindrical cross section; and, in a pad compression tube having a first open end to go over the sample collection pad and the second end of the handle, an opposing second end, an inner surface extending therebetween, and at least outlet port proximal to the pad compression tube second end and in fluid communication with the pad compression tube inside. The system may include where sufficient evidence is a light pipe, or other elements that showed, providing visual, aural or haptic indication of sufficient sample volume. The system may include where sufficient evidence includes longitudinal channel extending along the inner surface in contact with the sample collection pad to provide a way for displacement air. The system may include a sealing member to seal against a pad compression tube and perform specimen collection pad. The system may include one or more collection tubes attachable to one or more of the pad compression tube outlet port. The system may include ergonomic portion of the rod and pad compression tube. The system may include a specimen collection pad with a whole cross section of a reduced cross section portion, including a shoulder making a sealing member and an angled face to conform to the inner surface of a light pipe sufficiency indicator. The system may include one or more in-line filter next to the pad compression tube outlet port. The system may include additional features as described herein.

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